The overall goal of our work is to understand the mechanisms contributing to progressive renal injury in the mammalian kidney. In people and animals with chronic renal disease, there is a tendency for kidney function to deteriorate over time, despite currently available therapeutic options. A variety of contributory mechanisms have been proposed, including hypertensive renal injury, disordered cellular proliferation, and disruption of biochemical pathways within renal cells.
Our current research is directed along two parallel paths: 1) elucidating the mechanisms of progressive renal injury, and 2) developing novel therapies that effectively slow the progression of renal failure.
Both integrative physiological and cellular biological techniques are currently employed in the laboratories. These methods include renal micropuncture, radiotelemetric measurement of blood pressure, and renal mesangial cell culture studies.
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